single monthly dose vitamin d
The randomization process was supervised by the study biostatistician (A.W.S.) Daily dosing results in a fairly steady level of serum D3 with little fluctuation and risk for depletion, whereas weekly dosing (taking a single dose at 7 times the daily dose, once per week) causes a spike in vitamin D3 level, which then quickly drops and leaves the blood vitamin D3 depleted.
Antihypertensive effects could also occur through improvement in endothelial function and a reduction in vascular tone.44 We showed that this could be associated with a decrease in arterial stiffness, as PWV was lowered by vitamin D (Table 3). Materials provided by The JAMA Network Journals. Setting and participants: A total of 200 community-dwelling adults 70 years and older with a prior fall event in the last year. Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. Although effects on brachial BP were in the negative (lowering) direction, they were non‐significant, unlike those for central BP parameters (Table 3). Regular price © The Author(s) 2019. Until that approach is supported by randomized trials with updated meta-analyses, it would be prudent to follow recommendations from the Institute of Medicine (IOM) that people 70 years or older have a total daily intake of 800 IU of vitamin D without routine measurement of serum 25 (OH)D levels. Figure 2. Random assignment to one of the 2 treatment groups was made with random block sizes of 8, 10, or 12, within ethnic and 5‐year age groups.
Baseline group differences in characteristics and differential missingness of data were assessed with ANOVA (for continuous variables) and the chi‐square test (for categorical variables). This study was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12611000402943). Baseline characteristics of these participants by treatment group are given in Table 1. It is not intended to provide medical or other professional advice. Unauthorized An ASCOT (Anglo‐Scandinavian Cardiac Outcome Trial) substudy, Wave reflection and arterial stiffness in the prediction of 15‐year all‐cause and cardiovascular mortalities: a community‐based study, The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index, Wave reflection quantification based on pressure waveforms alone‐methods, comparison, and clinical covariates, A comparison of different approaches to unravel the latent structure within metabolic syndrome, Estimating mean annual 25‐hydroxyvitamin D concentrations from single measurements: the Multi‐Ethnic Study of Atherosclerosis, Vitamin D deficiency and mortality risk in the general population: a meta‐analysis of prospective cohort studies, Vitamin D and mortality: individual participant data meta‐analysis of standardized 25‐hydroxyvitamin D in 26916 individuals from a European consortium, The relationship between parathyroid hormone and 25‐hydroxyvitamin D during and after pregnancy, No adjustments are needed for multiple comparisons, Effect of vitamin D supplementation on insulin kinetics and cardiovascular risk factors in polycystic ovarian syndrome: a pilot study, High‐dose versus low‐dose vitamin D supplementation and arterial stiffness among individuals with prehypertension and vitamin D deficiency, The effect of vitamin D supplementation on arterial stiffness in an elderly community‐based population, Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin D deficiency: an exploratory, double blind, randomised controlled trial, The effect of high‐dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes, The effect of high dose cholecalciferol on arterial stiffness and peripheral and central blood pressure in healthy humans: a randomized controlled trial, Differential effects between a calcium channel blocker and a diuretic when used in combination with angiotensin II receptor blocker on central aortic pressure in hypertensive patients, Effect of monthly high‐dose vitamin D supplementation on cardiovascular disease: the vitamin D assessment study (a randomized controlled trial), Stratification of randomization is not required for a pre‐specified subgroup analysis, Journal of the American Heart Association, Effect of Monthly, High‐Dose, Long‐Term Vitamin D Supplementation on Central Blood Pressure Parameters: A Randomized Controlled Trial Substudy, Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta‐Analysis, Effect of Vitamin D Supplementation on Arterial Stiffness and Central Blood Pressure Indexes: Demystifying the Evidence.
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